Oxytetracycline injection 10%

Name

Oxytetracycline injection 10%

Composition

Each ml contains: Oxytetracycline 100mg

Character

The product is yellow to light brown-yellow clear liquid.

Pharmacological action

Oxytetracycline is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Oxytetracycline is active against a wide range of gram-negative and gram-positive organisms. The drugs in the tetracycline class have closely similar antimicrobial spectra and cross resistance among them is common. Micro-organisms may be considered susceptible of the M.I.C. (Minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate  if the M.I.C.is 4.0 t0 12.5mcg/ml.

Pharmacokinetics

Oxytetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile and excreted in the urine and faeces at high concentrations and in a biologically active form. Oxytetracycline is the least lipid soluble derivative among tetracycline class.

Indications

Oxytetracycline is indicated in infections caused by the following micro-organisms. Rickettsiae (rocky mountain spottedfever, typhus fever and the typhus group. Q fever. rickettsial pox and tick fevers). Mycoplasma pneumoniae agents of psittacosis and ornithosis agents of lymphogranuloma venereum and granuloma inguinale; the spirochaetal agent of relapsing fever(Borrelia recurrentis).

Infection caused by the following gram-negative micro organisms: Hemophilus
ducreyl (chancroid). Pasteurella pestis and P. tularensis, Bartonella  bacilliformis, Bacteroides species, Vibrio Comma and Vfetus, Brucella species (In conjunction with streptomycin).
Oxytetracycline is indicated for treatment of infections caused by the following
gram-negative and gram-positive micro-organisms, when bacteriologic testing
indicates appropriate susceptibility to the drug.
Gram-negative: Escherichia coli, Enterobacter aerogenes, Shigella species, Mima species and Herellea species, Haemophilus influenzae (respiratory infections), klebsiella species (respiratory and urinary infections).

Gram-Positive: Streptococcus Species-up t0 44% of strains of S. pyogenes and 74 of S. Faecalines have been found to be resistant to tetracycline drugs. Therefore, Oxytetracyclines should not be used unless the organism has been demonstrated to be sensitive. Tetracycline are not the drugs of choice in the treatment of any type of staphylococal infections. When penicillin is contraindicated tetracyclines are alternative drugs in the treatment of infections due to Neisseria gonorhoeae. Treponema pallidum and T.pertenue (syphilis and yaws) Listeria monocytogenes, clostridium species, Bacillus anthracis, Fusobacterium fusiform(vincent's infection),Actinomyces species N.meningitidis (IV only).

Clinical application

Gram-negative and Gram-positive bacteria, include Brucella, Francisella, Pseudomonas pseudomallei, Neisseria gonorrhoea, and Treponema pallidum.
Many Pasteurellae and Borrelia hurgdorferi(Lymedisease),Q fever and Rocky Mountain Spotted Fever, Mycoplasmas and Chlamydia
Often pneumonia and genitourinary tract infections
Psittacosis - Chlamydia psittaci
Malaria and ameobiasis in combo with other drugs

Contraindications

contraindicated inanimals who have shown hypersensitivity to any of the tetracyclines

Dosage and administration

Deep Intramuscular Injections:
Cattle, Horse, Camel, Sheep, Goat, Pig:
10mg-20mg per kg body weight

Withdrawal time

Meat: 7 days
Milk: 28 days

Shelf life

3 years

Warning

Animal studies indicate that oxytetracycline crosses the placenta and found in fetal tissues and can have toxic effects on the developing foetus (often related to retardation of skeletal development)
Evidence of embryotoxicity has also been noted in animals treated early in pregnancy The usage of Oxytetracycline during tooth development (last half of pregnancy, infancy) may cause permanent discolouration of teeth (Yellow-Grey-Brown). Therefore should not be used in this age group unless other drugs are not likely to be effective or are contraindicated. Oxytetracycline are present in the milk of lactating animal who are taking this drug.

Precaution

Oxytetracycline intramuscular solution should be injected well within the body of a relatively large muscle. As with all intramuscular injections aspiration  is necessary to help avoid inadvertent injection into a blood vessel. lf any super infection occurs the oxytetracycline should be discontinued and appropriate therapy instituted. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, It is advisable to avoid giving tetracycline drugs in conjunction with penicillin.

Storage

Keep in cool and dark place. Keep out of the children.

Packing

100ml per bottle