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Oxytetracycline injection 20%
Product Details
Name
Oxytetracycline injection 20%
Composition
Each ml contains: Oxytetracycline 200mg
Character
The product is yellow to light brown-yellow clear liquid.
Pharmacological action
Oxytetracycline is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Oxytetracycline is active against a wide range of gram-negative and gram-positive organisms. The drugs in the tetracycline class have closely similar antimicrobial spectra and cross resistance among them is common. Micro-organisms may be considered susceptible of the M.I.C. (Minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C.is 4.0 t0 12.5mcg/ml.
Clinical application
Wide range of organisms including bacterial & protozoans
Gram-negative and Gram-positive bacteria
Examples include Brucella, Francisella, Pseudomonas pseudomallei, Neisseria gonorrhoea, and Treponema pallidum.
Many Pasteurellae and Borrelia hurgdorferi(Lymedisease)
Common in Vet Med
Combination with sulfas (e.g., Sulfadimethoxine [Albon] with which they are
synergistic. Used to treat most Streptococcus, Staphylococcus, Pasteurella
infections in cattle [Bowersock 1995].
Rickettsial infections
eg.,Q fever and Rocky Mountain Spotted Fever, Mycoplasmas and Chlamydia
Often pneumonia and genitourinary tract infections
Psittacosis - Chlamydia psittaci
Malaria and ameobiasis in combo with other drugs
Demeclocycline-
SIADH - syndrome of inappropriate (excess) antidiuretic hormone
Non - infections
Inhibits ADH-included water reabsorption
Contraindications
The drug is contraindicated inanimals who have shown hypersensitivity to any of the tetracyclines.
Animal studies indicate that oxytetracycline crosses the placenta and found in fetal tissues and can have toxic effects on the developing foetus (often related to retardation of skeletal development)
Evidence of embryotoxicity has also been noted in animals treated early in pregnancy The usage of Oxytetracycline during tooth development (last half of pregnancy, infancy) may cause permanent discolouration of teeth (Yellow-Grey-Brown). Therefore should not be used in this age group unless other drugs are not likely to be effective or are contraindicated. Oxytetracycline are present in the milk of lactating animal who are taking this drug.
Precautioons
Oxytetracycline intramuscular solution should be injected well within the body of a relatively large muscle. As with all intramuscular injections aspiration is necessary to help avoid inadvertent injection into a blood vessel. lf any super infection occurs the oxytetracycline should be discontinued and appropriate therapy instituted. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, It is advisable to avoid giving tetracycline drugs in conjunction with penicillin.
Adverse reactions
Local imitation may be present after intramuscular injection of oxytetracycline.
Gastro intestinal; anorexia, nausea vomiting diarrhoea, glossitis duphagia,
enterocolitis, inflammatory lesions and hypersensitivity reactions haemolytic anemia thrombocytopenia, neutropenia and eosinophillia have been reported.
Dosage and administration
Deep Intramuscular Injections:
Cattle, Horse, Camel, Sheep, Goat, Pig:
10mg-20mg per kg body weight
Withdrawal time
Meat: 7 days
Milk: 28 days
Shelf life
3 years.
Storage
Keep in cool and dark place. Keep out of the children.
Packing
100ml per bottle